NFL picks, predictions against the spread Week 16: Bills pay off Patriots; The Chiefs crush the Steelers; Colts keep winning

Week 15 in the NFL brought some major surprises to disrupt our game picks and ATS predictions. With Christmas Day approaching mid-week 16, there won’t be any gimme game giveaways this week either.

There are some pretty big numbers when it comes to big favorites, as well as plenty of narrow favorites in contests featuring two bad teams. All 32 teams are in action again, and hopefully the full 16-game roster won’t see a schedule change.

Without further ado, here are our latest intrepid pigskin prognosis predictions, hoping for a great holiday:

(Game odds reflect the opening odds for Week 16, courtesy of FanDuel )

The Packers move up to No.1 as the Buccaneers and Cardinals fall; The bosses, the cowboys get up

NFL picks, predictions against the spread Week 16: Bills pay off Patriots; The Chiefs crush the Steelers; Colts keep winning
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NFL picks ATS for week 16

Sunday 1 p.m. ET, CBS

The Bills found something in last week’s running game against the Panthers and also made their passing game more dangerous by releasing Gabriel Davis to complete Stefon Diggs as wide receiver. They should be more relentless with the running game with Devin Singletary supporting Josh Allen as they adjust to handle the Patriots one-dimensional game plan with Mac Jones. Bill Belichick cheated on them once, but the staff limitations showed up here during the Buffalo rematch.

Take: Bills win 20-17.

Thursday 8:20 p.m. ET, NFL Network

The 49ers roll offensively with Jimmy Garoppolo spreading the ball and the running game picks up again. The Titans can slow them down a bit on the ground and contain tight end George Kittle. The big problems will be wide receivers Deebo Samuel and Brandon Aiyuk. The Titans don’t have the firepower in their heavy offense around Ryan Tannehill to score enough.

Take: The 49ers win 23-20 but fail to cover the gap.

  • Lock of the week: Chargers (-9.5, 46.5 o / u) on the Texans

Sunday 1 p.m. ET, CBS

The Chargers are well rested and will be ready to deploy more electric attacks with Justin Herbert in a great overall position. The Chargers are fading into the AFC West battle, but those are solid bets to secure a wild card spot in the first season under Brandon Staley. The Texans will play a little more offensive again with rookie QB Davis Mills, but they can’t stop much of what Los Angeles is doing well.

Take: The Chargers win 34-17 and cover the gap.

NFL picks, predictions against the spread Week 16: Bills pay off Patriots; The Chiefs crush the Steelers; Colts keep winning
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  • Upset of the week: Vikings (+3, 49.5 b / u) vs. Rams

Sunday 1 p.m. ET, Fox

The Vikings are getting ready to play Monday night. The Rams will have played Tuesday night. Minnesota tend to play top-down against their opponents, which leads to close and consistent games. Matthew Stafford looks back on an NFC North position in a different uniform and will manage to pitch the pitch, but he will also face a lot of pressure. Kirk Cousins ​​can use his weapons to bypass the Rams’ defensive forces from the comforts of home.

Take: Vikings win 27-24.

Saturday 4:30 p.m. ET, Fox Network / NFL

The Packers can smell another No.1 seed in the NFC playoffs and won’t be in a generous mood at Lambeau Field this Christmas. The Browns are hoping for another spot in the AFC playoffs, but their injuries and other issues have held them too back to give them enough time to recover. Aaron Rodgers is back in a happy mood with all his guns and may feel better about his home defense as well.

Take: The Packers win 27-17 and cover the gap.

  • Colts at Cardinals (-2.49.5 o / u)

Saturday 8:15 p.m. ET, NFL Network

The Colts are not changing their game plan of playing strong defense, stopping the run and containing passing play with versatile cover men in the last seven. It’s not a good way to get Kyler Murray out of a crisis given the shocking Lions result last week. The Cardinals have also caused significant leaks in their race defense and the Colts face another team where their intensive approach with Jonathan Taylor is the ideal approach.

Take: The Colts win 24-20.

NFL picks, predictions against the spread Week 16: Bills pay off Patriots; The Chiefs crush the Steelers; Colts keep winning
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  • Buccaneers (-11, 44.5 o / u) at Panthers

Sunday 1 p.m. ET, Fox

The Buccaneers’ passing game suddenly faces issues around Tom Brady with Mike Evans and Chris Godwin injured on wide receiver, but Antonio Brown’s return to bolster Rob Gronkowski is a big help. Just like the Bucs’ ability to handle the ball well, whether with more Leonard Fournette or Ronald Jones. The Bucs’ defense hasn’t collapsed against the Saints and will take on Cam Newton hard.

Take: The Panthers win 27-10 and cover the gap.

Sunday 1 p.m. ET, Fox

The Giants have a quarterback mess and their offense isn’t much more offense when it doesn’t give Saquon Barkley or another running back some key touches. However, their defense still plays with pride for Joe Judge, and the Eagles will make it a tougher game with plenty of runs in a very short week. Philadelphia slams the door with excellent defense in a slight victory.

Take: The Eagles win 20-13 but fail to cover the spread.

Sunday 1 p.m. ET, CBS

The Bengals have control of AFC North thanks to their victory over the Ravens in Baltimore in Week 7 and won’t pass up a chance for a formidable breakthrough season here. The Ravens’ defense can’t stop much in the passing game with all the injuries and Joe Burrow will light them all over the pitch for the second time. The Ravens will do their best with those who run and pass to stay competitive, but they are outmatched.

Take: The Bengals win 31-27 and cover the gap.

NFL picks, predictions against the spread Week 16: Bills pay off Patriots; The Chiefs crush the Steelers; Colts keep winning

  • Lions at Falcons (-3.5, 43.5 o / u)

Sunday 1 p.m. ET, Fox

The Lions have had a few flashes with new coach Dan Campbell. The Falcons enjoyed their part with new coach Arthur Smith. The Lions soar after beating the Cardinals, while the Falcons can appear deflated after the 49ers defeat. But Detroit has already seen the highlight of an otherwise lost season. Atlanta would like to finish strong outside the division. He wins with a few more defensive responses.

Take: The Falcons win 23-20 but fail to cover the spread.

  • Jaguars at Jets (-2.5, 42 o / u)

Sunday 1 p.m. ET, SCS

The Jaguars did not do well with Trevor Lawrence with Urban Meyer and Darrell Bevell during his rookie season as the No. 1 overall pick. The Jets have done their best to lift Zach Wilson under Robert Saleh and Mike LaFleur, but his progress as a second overall pick has been hampered by injuries and a declining supporting cast. Wilson has had a few more important individual moments than Lawrence and his team are a little more cohesive and motivated in a draw game.

Take: The Jets win 20-17 and cover the gap.

  • Bear to Seahawks (-7.43.5 o / u)

Sunday 4:05 p.m. ET, Fox

The Bears have a long way to go in a short week, but it’s even shorter for the Seahawks. Justin Fields is a good spark for the offense and the Seahawks have several holes he can exploit knowing his team will have immediate success with David Montgomery. Russell Wilson can attack the Bears’ weakened pass defense a bit better and also use his run well enough to preserve a necessary cosmetic victory.

Take: The Seahawks win 23-19 but fail to cover the spread.

NFL picks, predictions against the spread Week 16: Bills pay off Patriots; The Chiefs crush the Steelers; Colts keep winning
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  • Broncos to Raiders (-1.5, 42.5 b / u)

Sunday 4:25 p.m. ET, CBS

The Broncos lost to the Raiders 34-24 at home in Week 6. Those two teams are even too much to think the Las Vegas fading will sweep away the series this season. Denver can crush that too with their typical 1-2 punch from Javonte Williams and Melvin Gordon. Derek Carr and his guns crumble with their limits and Vic Fangio’s defense will crush them on the road.

Take: The Broncos win 19-17.

  • Steelers at Chiefs (-10, 46.5 y / u)

Sunday 4:15 p.m. ET, CBS

The Steelers played a much better defense against the Titans to help them win a low scoring game. But they also gave up a ton in the running game and got a team break with almost no real passing play. This is not the case against Clyde Edwards-Helaire, Darrel Williams, Patrick Mahomes, Tyreek Hill and Travis Kelce. Kansas City is playing like a team possessed and focused on another No.1 seed, while Pittsburgh is on the verge of retiring from the playoffs.

Take: The Chiefs win 34-17 and cover the gap.

  • Washington Football Team at Cowboys (-10, 47.5 o / u)

Sunday 8:20 p.m. ET, NBC

WFT and Dallas played a few weeks ago. The Cowboys handled this game well on the road, but almost let Washington come back late in the game. After a short week, the football team, with no chance of winning the division, will kick into action with limited offense against full and searing defense. Dak Prescott is using this favorable home game as a much needed update.

Take: The Cowboys win 33-14 and cover the gap.

  • Dolphins to Saints (-3, 40.5 o / u)

Monday 8:15 p.m. ET, ESPN

The Dolphins’ defense fueled their winning streak, supported by the running game going above and beyond to lift an efficient Tua Tagovailoa moving to his various weapons. They struggled with the pass at times but cleaned things up against the run. Miami are more versatile and multiple on both sides of the ball, while New Orleans limitations cost them another home game against an AFC East foe.

Take: Dolphins win 17-13.

Vinnie Iyer’s 2021 Picks:

  • Week 15 record against the spread: 8-8
  • Week 15 record: 12-4
  • Season ATS: 123-99
  • Direct season: 149-74

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